Diabetes Health Profile Scores are Associated with Diabetes-related Complications and Comorbidity

Findings to be presented at the ISPOR 16th Annual European Congress (November 2nd-6th) show  that higher scores (increasing dysfunctioning) on the Psychological Distress, Barriers to activity and Disinhibited eating domains of the Diabetes Health Profile (DHP-18) are statistically associated with a range of variables, including diabetes-related complications, duration of diabetes and comorbidity.

Using data derived from a sample of Type 1 and Type 2 people with diabetes (n=1,802) collected in one United Kingdom health authority area  and ordinary least squares regression to assess the relationship between DHP-18 domain scores (dependent variables) and clinical indicators (independent variables), key findings included:

  • Increasing Psychological distress scores significantly associated with eye and foot related complications, depression and arthritis
  • Duration of diabetes, eye and foot related complications, depression and lung disease were associated with increased perceived barriers to activity
  • Disinhibited eating was associated with depression and and anxiety

In addition there was initial evidence of an association between change in DHP-18 domain scores and change in severity of some clinical conditions at 12-month follow-up.

While based on one study these findings indicate that the DHP-18 might be an appropriate diabetes specific patient reported outcome measure for predicting therapeutic response and clinical success in some health areas.

Isis Outcomes will be presenting the poster at the conference:

  • Monday November 4th (15:30-19:30) – Poster Session II – PDB96: ASSESSING THE RELATIONSHIP BETWEEN THE DIABETES HEALTH PROFILE AND DIABETES SPECIFIC CLINICAL INDICATORS: CASE FOR TAILORED THERAPEUTICS. Mulhern B1;Meadows K2, Churchman D3
    1University of Sheffield, Sheffield, United Kingdom, 2DHP Research & Consultancy Ltd, Banbury, United Kingdom, 3University of Oxford, Oxford, United Kingdom

Dr. David Churchman will be in attendance at the poster during the author discussion hour (18:30 to 19:30 Monday 4th) for questions or introductions.

Isis Outcomes is an activity within Technology Transfer, part of Isis Innovation Limited, the Technology Transfer Company for the University of Oxford. Isis Outcomes is dedicated to the provision and support in use of high quality PRO measures to the Pharmaceutical and healthcare provider sectors.

What is the DHP-18?

The DHP-18 is a patient self-report diabetes-specific outcome measure of the psychological and behavioural impact of Type 1 and Type 2 diabetes. Used both nationally and internationally in a range of settings including clinical trials, population surveys and research, it has been completed by than 10,000 patients and was recently adopted by the UK Department of Health for their  Patient Reported Outcome Measures Pilot for Long Term Conditions in Primary Care programme.



Categories: Diabetes Health Profile, Patient reported outcomes

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